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Hydrophobic residues (such as Leu and Ala) cover the surface of the active cavity, which reduces the hydrophobic complementarity between the enzyme and the substrate, and further inhibits the catalytic efficiency (Hu et al., 2022b)

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Statistical analysis Data are expressed as mean standard deviation, unless indicated otherwise

5 , 8 , 10 , 12 As a tetracycline, doxycycline is contraindicated in children younger than eight years of age due to the risk of permanent tooth staining or enamel hypoplasia

Aoi W, Ogaya Y, Takami M, Konishi T, Sauchi Y, Park EY, Wada S, Sato K, Higashi A

Epstein-barr virus dUTPase induces neuroinflammatory mediators: implications for myalgic encephalomyelitis/chronic fatigue syndrome