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Intra-articular/soft-tissue injection: The dose depends on the size of the joint or lesion. A general guideline (from FDA labeling) is: Large joints (knee, ankle, shoulder) 2080 mg (0.52 mL); Medium joints (elbow, wrist) 1040 mg (0.251 mL); Small joints (fingers, toes) 410 mg (0.10.25 mL). Tendon sheath or bursa injections usually use 430 mg. For example, a knee might receive 40 mg once, while an inflamed finger joint might get 5 mg. Practitioners often aspirate synovial fluid first to confirm needle placement, then inject Depo-Medrol into the joint space. The joint is gently moved afterward to mix the steroid suspension. Repeat injections (if needed) are typically spaced by several weeks (e.g. 46 weeks) to monitor response and avoid excess steroid exposure

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B12 and Mixed-Ingredient Lipotropic Injections are administered into areas containing subcutaneous fat: buttocks, thighs, abdomen, and other problem areas

The recommendation for using the line of sight is user-friendly, personalized (the physician can instruct the patient on the spray usage technique based on a fast LoS check in the clinic), and has the potential to be smoothly incorporated into the nasal standard-of-care

The expression of genes related to DNA damage was changed in the cartilage of KBD patients 130,131

PMID 18172877