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Growing evidence indicated that microbiota dysbiosis, occurring when the diversity, composition, and/or functions of the intestinal microbiome are disrupted, could contribute to the alteration of the IEB with implications in the development, progression, and symptom flare-up of several diseases

How This Works The intestinal lining is a single layer of epithelial cells sealed together by tight junctions that control the paracellular pathway the space between cells and thereby regulate what passes from the gut lumen into the tissue

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