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These include the elderly, vegetarians and vegans, individuals with malabsorptive disorders (such as Crohn's disease, coeliac disease and post-bariatric surgery patients), those with pernicious anaemia, and individuals taking certain medications like metformin and proton pump inhibitors

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NNMT inhibition increases intracellular concentrations of NAD + and SAM in differentiated adipocytes Figure 3A outlines the major elements of the mammalian NAD+ salvage pathway using NA as the starting substrate.[27] Since the NNMT inhibitor 5-amino-1MQ significantly reduced intracellular 1-MNA concentrations (Figures 2B and 2C), we hypothesized that NNMT inhibition in adipocytes would increase intracellular concentrations of the co-substrates NA and SAM and shunt more NA into the NAD + salvage cycle

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