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J Histochem Cytochem 59(3):278288

allergens or environmental pollutants can also promote ROS production 12,14,16

Lactate, through HIF-1, promotes M2 polarization of TAMs, upregulates vascular endothelial growth factor (VEGF) and arginase-1(ARG-1) expression

The nitric oxide cycle closely relates to the urea cycle too - a necessary waste disposal system the body uses to breaks down ammonia in the liver and kidneys and excrete it as less toxic urea

In a mouse model of diabetic nephropathy induced by STZ, SFN attenuated hyperglycemia, polyuria, and polydipsia in wild-type mice, but not in Nrf2 KO mice [50]

James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al