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Previous studies have indicated that splicing factors could be transported to cytoplasmic stress granules upon stress such as hypoxia, heat shock, and chemotherapy 41,79,80,81,82

ACSL4 catalyzes the esterification of free AA and AdA with coenzyme A (CoA) to form PUFA-CoA derivatives (AA-CoA or AdA-CoA) (Kagan et al., 2017

4 Cardiomyopathy Based on etiology and pathophysiological characteristics, cardiomyopathy can be classified into genetic and acquired types, including dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and secondary cardiomyopathy caused by specific underlying conditions ( In addition to toxic factors, metabolic abnormalities also play a crucial role in the development of cardiomyopathy

276 Tirzepatide is associated with significantly greater proportion of achieving MASH remission with no worsening of fibrosis compared with placebo 277 in a phase 2 trial, and another phase 2 trial for dual agonism of glucagon receptor and GLP-1R (GCGR/GLP-1RA) survodutide demonstrated similar improvements in MASH

Smoking and environment-related lung injury Smoking is the most common environmental factor contributing to lung injury, and the respiratory tract is also chronically exposed to particulates, dust, smoke, and other inhaled toxins

Kern, L