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The mechanisms determining these differences are not currently known but may be related to differences in kinetics at different DSB repair sites, which varied from 1-10 hours in cultured human CML cells (15)

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Sekula P, Dunant A, Mockenhaupt M, Naldi L, Bouwes Bavinck JN, Halevy S, Kardaun S, Sidoroff A, Liss Y, Schumacher M, Roujeau JC (2013) Comprehensive survival analysis of a cohort of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis

These processes include the maintenance of ionic electrochemical gradients (Farsi et al., 2017), the regulation of ion channels (Becchetti et al., 2019), and the management of neurotransmitter release, uptake, and recycling (Armbruster et al., 2020