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This format supports reproducible handling, uniform exposure conditions, and reliable performance across nonclinical research workflows

Comment: Similar to the general comments on the proposed DCAPS fee schedule, as described above in section ( III.H.3.b, several commenters provided feedback on the Proposed NCD for Pre-Exposure Prophylaxis (PrEP) for Human Immunodeficiency Virus (HIV) Infection Prevention, published on July 12, 2023, as the NCD was not yet finalized as of the end of the comment period for the CY 2025 PFS proposed rule on September 9, 2024

While there's no official upper limit, doses up to 2,000 mcg can be safely used to treat B12 deficiency under medical supervision

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