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In short, cigarette smoking acts as a multifactorial disruptor, combining cytotoxicity, oxidative damage, hormonal imbalance, and apoptotic acceleration, to shorten reproductive lifespan and hasten the transition to menopause

Additional innovations such as self-immolative linkers and PEGylation strategies also show promise in enhancing pharmacokinetic profiles and controlling payload behavior [243, 244]

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The foods components can also affect and be affected by the intestinal microbiota, which is responsible for producing metabolites that act as allosteric regulators and cofactors of epigenetic processes (79)