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In summary, exercise combats MAFLD through dual mechanisms: downregulating PLIN5 to limit LD-mitochondria interactions and upregulating Mfn-2 to enhance PDM lipid metabolism, positioning it as a key strategy for NAFLD intervention

Any experiments involving the use of animals were conducted following the principles of laboratory animal care and were approved by the Institutional Ethics Committee, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University)

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207/19.09.2017), approved by the Scientific and Ethics Committee of Campania University Luigi Vanvitelli, Naples, Italy, and by the institutional review board (IRB Min No

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