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Based on these observations, detection of antibodies against EBV antigens has been established as a standard test for NPC in high-risk populations [16,18,19]

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Interestingly, both IR and IGF-1R are required for this effect of IGF-1 on mitochondria, which suggests that the hybrid IR/IGF-1R may be required for mediating the effect of IGF-1 on mitochondrial membrane potential and mROS production