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The competitive IRAP inhibitor 23 (HA08) enhances the numbers of dendritic spines in hippocampal cell cultures and HA08 treatment resulted in an increasing number of stubby and mushroom-like spines, a morphology typically associated with mature spines, which are believed to have strengthened synaptic connectivity

10.1016/j.neuroscience.2016.04.040 Neuroscience 188 YangY.RosenbergG

Psoriatic Arthritis Nails: The Most Overlooked Clue Nail involvement is one of the most diagnostically important features of this condition and one of the most frequently misread

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The Arp2/3 complex is an actin nucleation factor to mediate the formation of branched actin network (Goley and Welch, 2006), which is thought to be essential for spine remodeling during spine growth (Hotulainen et al., 2009)