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Boddu P, Borthakur G , Naqvi K, Wierda WG, Bose P, Jabbour E, Estrov Z, Burger JA, Alvarado Y, Deshmukh A, Patel A, Cavazos A, Han L, Kantarjian HM, Andreeff M, Konopleva M

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Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease

30 Also, the onset of acute pancreatitis occurred after 12 months in the LEADER trial and after more than five to six months in the SCALE trial, indicating that the likelihood of developing pancreatitis was influenced more by the rate and degree of weight loss than the drug itself

Mechanistically, they enhance anti-proliferative and anti-inflammatory activities, induce cell cycle arrest (G2/M phase), promote cell apoptosis, and modulate the activity of proteins such as P-gp and acetylcholinesterase [941,942,943]

Zhang X, Wang M, Zhou S