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Description

We find that CD epithelium exhibits reduced GPX4 activity and features of LPO

In colorectal cancer, the p185 protein encoded by the circular RNA circMYBL2 competitively binds to the deubiquitinase UCHL3, preventing UCHL3 from deubiquitinating PHGDH, which consequently leads to PHGDH degradation and suppresses serine synthesis and tumor progression (110)