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Abbreviations: TIR, time in range

Epi-nutrients as epigenetic enzyme cofactors In addition to functioning as substrates, nutrients also serve as vital cofactors that assist various enzymes in catalyzing epigenetic processes, further illustrating the complex role of nutrition in regulating gene expression (Donohoe and Bultman 2012)

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While the fermentable carbohydrates are reduced, the remaining material becomes concentrated in nutrients such as protein, amino acids, fats, minerals, and other fermentation substrates that support efficient yeast growth