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While the copper tripeptide contains histidine (which can be oxidized to 2-oxo-histidine), this residue is already coordinated to the copper ion, and the complexs high stability constant means the copper is not freely available for catalysis

Discussion 1) The study performed by Khavinson et al evaluated mesenchymal characteristics and neurogenic potential of hGMSCs and to investigate the molecular interactions and biological activity of the synthetic tetrapeptide Epitalon

GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper) is a naturally occurring copper peptide found in human plasma, saliva, and urine

Adv Funct Mater2023 Jul 9

10094-1-AP

selenium is an essential trace mineral