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As the disease progresses to stage 3, systemic hyperphosphatemia typically arises, further exacerbating systemic inflammation and vascular calcification, and consequently accelerating the process of early vascular aging (Voelkl et al., 2018)

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In an accelerated aging rat model, vitamin E supplementation reduced the number of nerve cells lost due to aging (La Fata et al., 2017), and improved memory and cognitive decline due to the loss of prefrontal cortical cells (Rafati et al., 2017)

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2.2.10.2 In vivo Animal Studies Several studies have demonstrated the antifibrotic and anti-inflammatory effects of PFD in experimental animal models, especially in bleomycin-induced pulmonary fibrosis models

Notably, this dietary pattern is abundant in dietary fibre, a distinctive feature associated with its health-promoting effects [115]