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This process included the assignment of bond orders, addition of hydrogens, generation of het states (with Epik), addition of missing amino acid side chains (with Prime), H-bond assignment by sampling water orientations, assignment of charge states at physiological pH (with PROPKA), and restrained optimization (with the OPLS4 force field 84 , to converge heavy atoms to an RMSD of 0.30 )

Kapetanaki, S., Kumawat, A

Since glutathione is becoming more popular as a skincare ingredient, many brands have created products formulated with this powerful antioxidant

(1999) Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2

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Mutations in the SOD1 gene, which encodes the antioxidant enzyme superoxide dismutase 1, represent a well-characterized genetic cause of familial ALS