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These macrophages modulate the immune response not only through direct contact but also by secreting cytokines, which play roles in immunoregulation, tissue remodeling, and process of fibrosis (Yang et al., 2023)

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Determination of superoxide dismutase (SOD) activity SOD activity was measured in the skin homogenate based on the Beyer and Fridovich method [4]

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Skeletal radiographs are also helpful in diagnosing the disease

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Since the S129p site is adjacent to the DEF/YxP motif, we speculate that elevated S129p levels under pathological conditions may induce local conformational changes that modulate the interaction with H2a-H2b, thereby interfering with chromatin regulation

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