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In fact, the profound ROS accumulation characteristic of sickle RBCs has been demonstrated to be mainly caused by NADPH oxidase, which is regulated by Rac GTPase [179]

4702-C DIFFERENTIAL RNA EXPRESSION AND EXPRESSION QUANTITATIVE TRAIT LOCI ANALYSIS IDENTIFIES NOVEL GENETIC VARIANTS ASSOCIATED WITH RECURRENT NONALCOHOLIC STEATOHEPATITIS (NASH) AFTER LIVER TRANSPLANTATION FOR NASH CIRRHOSIS Christopher Danford 1 , Richard Gilroy 2 , Nephi Walton 2 and Bryce Christensen 2 , (1)Intermountain Health, Millcreek, UT, (2)Intermountain Health Background: Despite identical recipient genetics and similar recipient environmental exposures, only a minority (10-40%) of patients transplanted for NASH cirrhosis develop recurrent NASH post-transplant

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