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The interaction of gene polymorphisms and Alzheimer's disease-related pathology on the progression rates for clinical and cognitive decline is an emerging area that will have implications for individual prognosis and therapy trial design

Sources The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis Journal of Personalized Medicine (2021) Vit B12 supplement of 500 g/d for eight weeks does not normalize urinary methyl-malonic acid or other biomarkers of vitamin B12 status in elderly people J Nutr

Unfortunately, studies have shown that about 6% of the people in the US are deficient in this vitamin and around 20% are borderline low

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Any suggestions apart of B12 injections and diet