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AUC 090min , area under the concentration/time curve at last observation

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84 , 173 Studies have shown that the combination of chemotherapeutic drugs (such as ADM and DDP) and the antimicrobial peptide -defensin can improve the sensitivity of multidrug-resistant breast cancer MDA-MB-231 cells to the chemotherapeutic drugs and effectively enhance the cytotoxic effect of such chemotherapeutic drugs

10.1016/j.bbi.2012.08.007 82