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Nonetheless, in a series of elegant experiments using human-induced pluripotent stem-cell-derived DAergic neurons homozygous for a DJ-1 loss-of-function mutation, which in mouse models does not result in decreased nigral DA or -synuclein aggregation and CRISPRCas9-mediated DJ-1 KO cells, the Krainc research team demonstrated that DA oxidation was sufficient to generate typical PD pathology [70]

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van Crevel et al., 2002

10.1016/j.freeradbiomed.2010.09.019 Free Radic