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The development of gastric cancer involves the following mechanisms that can activate the downstream signaling pathways (Table 3), including the cytokine-stimulated transduction (JAK-STAT) signaling, the nuclear factor B (NF-B) pathway, the Wnt/-catenin signaling pathway, the mitogen-activated protein kinase (MAPK) pathway, the Hippo pathway, the PI3K/Akt pathway, and other signaling pathways [92]

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