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Vitamin B12 deficiency and pernicious anaemia While pernicious anaemia accounts for a high proportion of cases of vitamin B12 deficiency, other causes include malabsorption or an inadequate dietary intake of vitamin B12 (see Table 1)[4,814]

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Upregulation of CD38 in patients with SSc, resulting from its induction by cytokines such as TGF-, IL-6 and senescent cell-derived SASP enriched in the fibrotic tissue microenvironment, will promote NAD + consumption and decline, which in turn impairs the function of sirtuins and other NAD + -dependent cellular enzymes