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When the FDA places a peptide in a restricted or high-risk category [known as Category 2], it is explicitly signaling that it has identified safety concerns and that enforcement discretion does not apply. But, as Hajduczok notes, just because something is not FDA-approved doesnt mean its illegal to compound, but the restricted peptides should not be compounded

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Secretogranin-3 (SCG3)-derived peptides also showed enrichment in frail brain, tentatively highlighting aberrant granin function with cognitive frailty

The compounds clinical file for hair, in the strict sense of controlled human efficacy trials, is close to empty