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Excess ROS destabilize mitochondrial electron transport chains, induce mtDNA mutations, and oxidize membrane lipids, all of which further impair immune resolution

10.1046/j.1432-1327.2001.02132.x 95 WangZ

A significant challenge in identifying biomarkers in ASD is that biomarkers may reflect genetic and neurobiological changes or epigenetic (broadly defined, see below) processes that may be active only during particular periods of time and do not define the disorder, only the process that led to it