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Because of the key sex differences in the effect of ES [240,241,242,243] and nutrition [244] and general metabolisms [245] and disease prevalence and presentation [238, 239], it is key for future studies to consider both sexes when assessing efficacy of nutritional interventions in ES research and to include sex as a discovery variable

Furthermore, CYP-generated eicosanoids likely are involved in more diverse physiological responses than previously appreciated

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In multiple cancer types, for example, melanoma, NSCLC, CRC and glioblastoma, CAFs promote drug resistance through secretion of factors, which could modulate multiple cancer cell phenotypes, such as EMT and quiescence 161 , as well as cancer cell signalling pathways 161,162

In conditions like dysautonomia and Postural Orthostatic Tachycardia Syndrome (POTS), the ANS loses its ability to properly regulate heart rate, blood pressure, and vascular tone