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L-Buthionine-(S,R)-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting g-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH) [2]

Billingham, L

It does not remove chemicals

The disruption of phytanic acid catabolism, due to inadequate levels of TPP, leads to triglyceride accumulation, which may cause deleterious effects such as cerebellar ataxia, peripheral polyneuropathy, vision and hearing loss, anosmia, and, in some instances, cardiac dysfunction and epiphyseal dysplasia (54)

however, after treating the cells using 50 nM SHBG, we could observe that the cells display a really slight signal which is related to the fact that there is no damaged DNA fragments (Fig

42 Because the Rumack-Matthew nomogram was solely derived from oral acetaminophen overdose patients, strictly applying the nomogram to determine toxicity following IV acetaminophen overdose may not be appropriate at this time