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As with other G protein-coupled receptors, GPER-1 is a seven-transmembrane domains receptor located at the plasma membrane, with its amino and carboxyl groups oriented to the extra- and intracellular environments, respectively (Figures 2, 3

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Adv Pharmacol 74:133 Walsh MC, Lee J, Choi Y (2015) Tumor necrosis factor receptor-associated factor 6 (TRAF 6) regulation of development, function, and homeostasis of the immune system

Epidermis (outer) where surface pigment sits

Abstract Inflammaging, the chronic increase in inflammatory signaling with age, remains poorly understood in hematopoietic aging