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Unique roles of Schistosoma japonicum protein Sj16 to induce IFN- and IL-10 producing CD4+CD25+ regulatory T cells in vitro and in vivo

the trials were small (ranging from 20 to 193 subjects) and their design was so different that results could not be generalized

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There are two situations here, namely short-term stress and long-term stress

Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis (Bansal et al., 2025)

Tariot PN, Farlow MR, Grossberg GT, Graham SM, McDonald S, Gergel I, et al