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Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction

Neuropharmacology 79:298306 Lu Y, Yang YY, Zhou MW et al (2018) Ketogenic diet attenuates oxidative stress and inflammation after spinal cord injury by activating Nrf2 and suppressing the NF-B signaling pathways

Three replicates of 5 s were performed for each system (WT and M105I) to analyze protein-membrane interactions

As a sulfur-containing amino acid, the conversion of methionine to cysteine is supposed to be enhanced under cystine limiting conditions

Overall, these findings highlight the importance of redox homeostasis and metabolic compensation in pathogen adaptation to the host environment and suggest new avenues for antifungal drug development