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Intrathecal administration, while conceptually the most direct way to approach brain iron, is highly invasive and currently studied only in experimental scenariosit may be considered in extreme cases or acute CNS iron toxicosis, but it is not a routine approach due to the safety and logistical challenges

Kinetics of the Yeast Cystathionine -Synthase Forward and Reverse Reactions: Continuous Assays and the Equilibrium Constant for the Reaction

10.1093/jn/103.10.1454 [PubMed: 4200872] [CrossRef] Oppermann JA, Muldoon E, Ranney RE (1973b)

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The accumulation of Akkermansia promotes intestinal mucosal barrier damage and gut inflammation, facilitating abnormal -syn aggregation within the intestine, which can ultimately lead to systemic inflammation [89]

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