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They have been approved for clinical application or are being evaluated in clinical trials for the treatment of advanced AMD or RP [256, 257]

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Similar mechanisms may be responsible for the enhanced vasodilatory action of peroxynitrite (ONOO) in the presence of GSH: peroxynitrite reacts with GSH to form S-nitrosothiols (RSNOs), which subsequently release NO over a prolonged period of time, thus extending NO's half-life and, as a result, relaxing vascular tone (25)