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mt-Keima is a mitochondria-targeted fluorescent protein, which is sensitive to pH changes but resistant to degradation mediated by lysosomal proteases

CDP promoted melanogenesis by activating MAPK signaling pathway and up regulating the expression of MITF and its downstream genes Tyr, TRP1 and Trp2, including increasing the phosphorylation levels of p38, JNK and ERK proteins

Winer S, Winer DA

Several mechanisms have been proposed to explain chronic hyperglycemia-induced nerve damage, such as intracellular accumulation of sorbitol, glycation reactions, and oxidative and nitrosative stress (reviewed in 69)

The first is Huppke-Brendel Syndrome, a severe neurodevelopmental disorder characterized by severe intellectual disability, motor deficits, and progressive neurodegeneration

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