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doi: 10.1016/j.neuron.2010.08.021 18 ChauhanA.SangwanN.SinghJ.PrakashA.MedhiB.AvtiP

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Human Data Congenital Malformations The North American Antiepileptic Drug Pregnancy Registry reported 16 cases of congenital malformations among the offspring of 149 women with epilepsy who were exposed to valproic acid monotherapy during the first trimester of pregnancy at doses of approximately 1,000 mg per day, for a prevalence rate of 10.7% (95% CI 6.3%-16.9%)

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