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E.CalderJ

Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice

Clinically reviewed by Adair Anderson, MS, RDN, LDN The brain relies on neurotransmitters to keep everything from mood to digestion running smoothly

Researchers used LPS to establish a severe pneumonia mouse model, and genomic analysis confirmed that pulmonary endogenous bacteria can translocate to the brain and drive the transition of microglia and astrocytes from a resting state to an activated state via infection-associated pathways, thereby disrupting brain homeostasis [262]

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