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Cochrane Database Syst Rev (10):CD005590 Zhou L, Dhopeshwarkar N, Blumenthal KG, Goss F, Topaz M, Slight SP, Bates DW (2016) Drug allergies documented in electronic health records of a large healthcare system

(480) reported that an increase in opportunistic pathogens, including Actinomyces , Erysipelaclostridium , Streptococcus , Veillonella , Rothia , and Enterobacter , was positively correlated with both the initial diagnosis and the severity of the illness

Treatment (section 6)

Here, we show that consumption of a common non-nutritive sweetener, sucralose, modifies microbiome composition, restricts T cell metabolism and function, and limits immunotherapy response in preclinical models of cancer and advanced cancer patients treated with anti-PD-1 based immune checkpoint inhibitors (ICIs)

Within hepatocytes, copper is chelated by metallothionein isoforms 1 and 2 (MT1/2), facilitating its storage

While the physiological pathways MOTS-c influences, such as the AMPK pathway, are highly conserved across species, the pharmacokinetics and ultimate clinical efficacy can differ significantly between mice and humans