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Furthermore, heterogeneity in tumour stage (or indeed, location), patient populations and treatment dose and duration is likely to confound reported response data, particularly given the links between changes in oxidative metabolism and metastatic spread 84,85,86,87

10.1016/S0167-4781(00)00029-4 61

doi: 10.3389/fnut.2025.1581848 Received 23 February 2025 Accepted 22 September 2025 Published 15 October 2025 Volume 12 - 2025 Edited by Roberta Zupo, University of Bari Aldo Moro, Italy Reviewed by Padhmanand Sudhakar, Kumaraguru College of Technology, India Edem E