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Because the demand for oxygen is much higher than the supply, these microenvironments tend to exhibit hypoxia and nutrient scarcity

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In a preferred embodiment, serviceable polynucleotide-acting enzymes are exemplified non-exclusively by enzymes with polynucleotide-cleaving activity, enzymes with polynucleotide-methylating activity, enzymes with polynucleotide-ligating activity, and enzymes with a plurality of distinguishable enzymatic activities (including non- exclusively, e.g., both polynucleotide-cleaving activity and polynucleotide-ligating activity)