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Additionally, right open reading frame kinase 2 (RIOK2), a member of the RIO kinase family that is highly expressed in GBM, was shown to enhance cell migration and invasion by upregulating MMP-2 and MMP-9

In an effort to improve the potency and efficacy of such inhibitors, some studies have discovered GPNA, which is widely used as a tool compound for suppressing SLC1A5 203