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The molecular basis of X-linked immunodeficiency disease

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546 ME Association

Polytarchou, Kali et al

CD8 + T cells release interferon- (IFN-), which downregulates the expression of SLC3A2 and SLC7A11, the two subunits of the System Xc , inhibiting cystine uptake by tumor cells and promoting ferroptosis (Wang et al

Taken together, we propose a model in which increased oxidative stress in TTR-V30M carriers, potentially promoted by misfolded TTR, contributes to reduced GSH availability [49, 50]