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However, in primary gastric tumors and cell lines of gastric cancer and in primary colorectal cancer, the fusion of coding region of SLC1A2 (EAAT2) with a region of a probable promoter of CD44 results in a truncated but overexpressed and functional protein EAAT2 (189, 258)

Loss- and gain-of-function experiments in mice demonstrate that osteoblast-derived LCN2 maintains glucose homeostasis by inducing insulin secretion and improves glucose tolerance and insulin sensitivity

10.1084/jem.20130315 J

This impairment of homeostasis initiates pathological changes, including mitochondrial dysfunction, lipid peroxidation, immune suppression, and the activation of proinflammatory pathways (Dey et al., 2024)

[64] Results from tasks assigned in studies comparing NF-1 + ADHD groups with children who have only ADHD suggest that NF-1 + ADHD is not simply a combination of both conditions, nor does ADHD merely exacerbate attention problems in NF-1

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