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Unprecedented blue intrinsic photoluminescence from hyperbranched and linear polyethylenimines: polymer architectures and pH-effects

Subsequently, insulin-stimulated tyrosine phosphorylation is decreased leading to impaired glucose transport and resistance (194)

S7C) and GSH (Fig

AMPK promotes autophagy directly by phosphorylating autophagy-associated proteins in the mTORC1, ULK1, and PIK3C3/VPS34 complexes [90, 103, 104] or indirectly by regulating the expression of autophagy-associated genes downstream of transcription factors (e.g., FOXO3, TFEB, and BRD4) [105,106,107]

Based on the above mechanism, combined therapeutic strategies targeting the T cell-ferroptosis axis have shown clinical potential: radiotherapy synergizes with immunity, and radiotherapy-induced ATM activation synergistically inhibits SLC7A11 expression with IFN- released by CD8+ T cells, significantly increasing lipid peroxidation levels and thus significantly enhancing the therapeutic effect of ferroptosis (223)