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When GSH levels are depleted, GPX4 activity is compromised, leading to unchecked lipid peroxidation and ferroptosis induction

this eventually results in ferroptosis (Su et al., 2020) (Figure 1)

4a) were heavily labelled with BioGEE and the signal was lost in each case upon treatment with DTT, which confirmed the specificity of the signal as due to a mixed disulfide