The concomitant impact aging has on astrocytes also induces a phenotypic switch that results in altered gene expression, perpetuation of inflammation, and recruitment of peripheral immune cells, which further exacerbates inflammation (Palmer and Ousman, 2018
Romano et al., 2021), and in mice also by a proliferation of Bacteroidales at the expense of Clostridiales (Figure 5
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Platelet surface glutathione reductase-like activity
This element is also present in Skincare products like Glutathione Face & Body Scrub that brighten and even tone, work as a powerful antioxidant, fight collagen production, and detoxify harmful elements
The scientific rationale for a nutritional approach Several studies have revealed in patients with vitiligo specific nutritional and biological characteristics that justify nutritional support: Major oxidative stress in melanocytes: justification for antioxidants (vitamin C, E, glutathione, selenium) More frequent deficiencies in vitamin D, vitamin B12, folate and zinc in several studies Melanin synthesis dependent on precursors (tyrosine, phenylalanine) and enzymatic cofactors (copper, zinc) Documented action of certain plants (Ginkgo biloba, Polypodium leucotomos) in randomized clinical trials What the nutritional approach does not do Let's be clear and honest: It does not cure vitiligo It does not replace medical treatments It does not work for all patients Results are not guaranteed What it can do Support the physiological mechanisms of repigmentation Address nutritional deficiencies commonly found Reduce oxidative stress documented in patients Enhance the efficacy of phototherapy according to several studies Fit into a holistic approach with healthy lifestyle habits and medical follow-up The nutritional approach is therefore positioned as a complementary tool , never central, but which can have its place in a comprehensive management plan
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