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HuangDTAyraultOHuntHWTaherbhoyAMDudaDMScottDCet al

FANCB cells were sensitive to FA and this phenotype was largely exacerbated by blocking GSH synthesis (Fig

However, when APAP is ingested in excessive amounts, the capacity of GSH to neutralize NAPQI becomes overwhelmed, leading to depletion of hepatic GSH stores and accumulation of NAPQI, resulting in oxidative stress, mitochondrial dysfunction, and hepatocellular injury, ultimately culminating in acute liver injury and potential liver failure