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Juglone is also an efficient inhibitor of the ChaC1 paralog, ChaC2 ChaC2 is a homolog of ChaC1, and higher eukaryotes including humans have both ChaC1 and ChaC2 present in their cytosol responsible for glutathione degradation

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Data from the TCGA database reveal overexpression of GLS1 in various solid tumors, including stomach adenocarcinoma, head and neck squamous cell carcinoma, thymoma, testicular germ cell tumors, HCC, colon adenocarcinoma, and others

Importantly, the GM was determined to be more resilient to the lowered pH than the skin microbiota, likely because the GM are naturally exposed to acidic pH from gastric sections, and the researchers speculated that the dysbiosis they observed resulted from host physiological stress rather than directly from acute acidic exposure

Figure 1) is mainly produced by the kidney (Olson et al., 2008) and GPX3 was detected in human CSF (Solovyev et al., 2013