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These genomic insults within the mitochondria lead to impaired oxidative phosphorylation (OXPHOS) and a significant reduction in the activities of electron transport chain (ETC.) complexes (Xu and Wen, 2023

Ital J Pediatr 2012

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The [2Fe-2S] cluster may be formed by the fusion of two [1Fe-1S] precursor units, which challenges the traditional model of adding atoms one by one on a scaffold protein