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The dysfunction and degeneration of neurons of the deep cerebellar nuclei give rise to gait ataxia, progressive loss of motor coordination, dysarthria and saccadic eye movement alterations frequently seen in FRDA patients [97]

Complete abstinence is therefore a reasonable lifetime recommendation

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doi: 10.1016/j.jacc.2018.08.2180 9 De GeestBMishraM

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